Thiamine reddit. Itchiness, like histamine effect.
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At the height of being underweight my skin looked gray. Maybe ease up on the thiamine for a little bit if you’re getting reflux. So the story begins in 2022 last summer I was getting ready to cut back on drinking. Elliot Overton has some amazing videos on YouTube about it. "Vitamin B1, thiamin, or thiamine, enables the body to use carbohydrates as energy. Without thiamine, the other B’s are not utilized properly. I too have noticed my skin isn't as thin and I don't look as destroyed. In my endless search for new things to try, I came across some videos and articles touting thiamin/thiamine/b1 supplementation for mood, energy, fatigue, and nervous system regulation among other things. I’d say my overall fatigue level has improved by 50-80%. Thiamine can reduce lactate and ammonia in the body, as well as increasing CO2. Also, this goes against the subreddit, but I realized I'm able to tolerate caffeine as I used to years back, since I've recently been upping my thiamine. Easy internet search…Here is a list from Dr. This procedure of increasing dosage was followed because even low doses on normal individuals or on individuals who do not need vitamin supplements may show side effects such as tachycardia, anxiety The triad of vitamin B1-deficiency (Thiamine-deficiency) and Wernickes encephalopathy is confusion, poor balance and problems with eye movements (or double vision). Thiamine deficiency in Covid patients馃摲 Has thiamine supplementation helped anyone with Covid at any stage? Has it been discussed or recommended? Interested in personal experience or research. I also orderd benfotiamine which is fat soluble, more bioavailable form of thiamine this one easily gives you paradoxical reaction even though it's more effective than thiamine HCL. Vitamin B1 and magnesium are co-factors, so they need each other. No but I'd believe it. While I don't know for sure, it is entirely possible that cross contamination now is inhibiting my body from readily absorbing thiamine or other vitamins. There is no upper tolerable limits for thiamine. As of recently dealing with some sudden onset anxiety over the last 5 months I figured id' try it and I had high hopes it was gonna get me back to feeling like how I felt before I started experiencing this. Thiamine TTFD has been shown to influence neurotransmitter production, including dopamine, which plays a crucial role in mood regulation. 47K subscribers in the cfs community. Which I learned the pure thiamine form, doesn't absorb into fat, or get levels of thiamine up in the brain. Work your way up to 1500mg thiamine a day for a month or two. Thiamine is necessary for glucose metabolism, which is the primary energy source for the brain. Considering your recent experiences, it might be beneficial to lower your thiamine dosage back to 50 mg or even 25 mg to see if your symptoms improve. Benfotiamine and TTFD are much more bioavailable than the thiamine salts (HCL and mononitrate), with TTFD being the most bioavailable. Search for thiamine deficiency. When thiamine is reintroduced and things get turned back, your body goes haywire until the chemistry can normalize. Helps to flush the glymphatic system. I started taking 500mg of Thiamine (vitamin B-1) every day and noticed an improvement in just a week. Nothing comes close it has essentially it's own delivery system. Get the Reddit app Scan this QR code to download the app now There is a lack of evidence of toxicity from high thiamin intake from food or supplements. I would start taking 500mg thiamine HCl a day with 200-400mg magnesium. Basically, I’ve been raising the dose after I stabilize on that dose. 9 percent report using oral thiamine mononitrate, and another 5. Mg replacement therapy can take several months before replenishing stores. One can present with all or only one of the symptoms. I myself am glutamate sensitive/get excito from things that promote glutamate, and am histamine intolerant. There's also pantethine, which is the form of B5 that crosses to the brain and, like sulbutiamine or TTFD, uses a disulfide bridge. Some experience worsen of symptoms for about a month before they improve. You should ask for a blood test, because too much of certain vitamins can actually make you more sick. Why YSK: It takes extra thiamine and folic acid to process alcohol, leading to deficiency if the individual does not supplement. After a week you should start to feel a difference. Axe of the top thiamine-rich foods to include in your diet: Nutritional yeast: 2 tablespoons — 9. As expected, the first 4 weeks I had a paradoxical reaction - lethargic, stronger brain fog and somewhat anxious. Dude YES. I take about 1200% of the RDA every day. Sulbutiamine is the most commonly recommended thiamine analogue on r/Nootropics, but is there something better out there for improving mental performance?I've read that Allithiamine is superior, but it seems quite expensive (cheapest I've found is $15 for 60 caps, any sources on bulk powder would be appreciated). Is it MANDATORY of take B1 with magnesium or just a recommendation? I am taking Mg malate now and gives me good energy. I have tested positive for thiamine deficiency multiple times. I started taking about 100mg. It can cause all kinds of problems. You can start by simply taking 10-50mg thiamine HCL from reputable brand, and make sure you get enough of other B-vitamins from diet (eggs, liver, meat, etc), potassium (fruit, coconut water, etc) and magnesium (100-200mg per day). Thiamine’s chemical structure. Many forms of Thiamine. What God made is better. Bryan recommends taking sublingual vitamin B1, and I ordered this brand: Superior Source "No Shot" Vitamin B1 (Thiamin), 100 mg, Under The Tongue Quick Dissolve Sublingual Tablets, 100 Count I researched magnesium and went with glycenate form and then started adding thiamine after 3 days of magnesium, now i can eat some carbs now and zero body aches, no more anxiety, brain fog and the most i went the bathroom after eating some gluten and sugar, only went the bathroom 3 times the next day. Swallowed on and the 7 I had removed were like ten years old decayed and leeching. This. I take… Ya there's a big difference between say thiamine hydrochloride and TTFD or Allithiamine. It also helps produce neurotransmitters, chemicals that transmit signals between nerve cells. He explains different forms of thiamine like thiamine hcl, Benfotiamine. I take a ton of thiamine and it has helped significantly. Thiamine is a vital vitamin for people to eat. I am learning now about the very close relationship between thiamine and magnesium…I think I potentially increased my need for thiamine quite a bit and wasn’t even aware. Jun 17, 2024 路 With longstanding thiamine deficiency, the human body changes its chemistry to adapt and survive. 6 mg (640 percent DV*) Seaweed (such as spirulina): 1 cup seaweed — 2. Exactly this. It makes a huge difference especially if youve been drinking a lot and not eating well. See full list on healthline. Thiamine is essential for absorbing nutrients and protecting nerve cells. As a water-soluble vitamin, thiamine rapidly breaks down once it’s consumed and is flushed from the body more easily than fat-soluble vitamins, which can accumulate. 14536 "Thiamine deficiency disorders: a clinical perspective" (2020) "While thiamine deficiency is clinically diagnosed as an isolated micronutrient deficiency, it could certainly coexist with presentation-altering deficiencies of other vitamins and minerals (e. Thanks for your post, I will also look into Thiamine. Low Thiamine can cause cause palpitations, a lack of energy, increased heart rate, shortness of breath etc. The "thiamine" part is wrapped with the "lipid" part of BFT so the molecular weight of BFT is greater than the molecular weight of thiamine HCl or nitrate. As a current drinker (and former heavy drinker for ~6months) I experience similar (though less pronounced) positives, and none of the negatives you list. If there's a Nov 18, 2020 路 In rats, high-dose thiamine post-cardiac arrest restored pyruvate dehydrogenase activity in brain, mitochondrial respiration, improved neurological function, reduced brain injury, and improved survival at 10 days. Sulbutiamine has unique effects on the brain that regular thiamine doesn’t have. I get little to no reflux when I take thiamine. xx Thiamine is needed to produce hydrochloric acid. Thiamine deficiency also messes up your electrolyte metabolism as it wastes potassium when you dont have proper thiamine stores. Which matters a lot. Archived post. Important fact about this form of pure, smelly thiamine. This can progress to Korsakows-syndrome if left untreated, with confusion and memory loss. It's interesting though, taking Thiamine HCl allowed me to eat a lot more foods! I still have food intolerances, but not as many or as intense as before. This is one of the types of Thiamine with the lowest bioavailability and if I remember correctly, doesn't cross the Blood Brain Barrier. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine. The headache vitamins took a few weeks to help. The treatment is thiamine supplementation. com Thiamine should be taken 30 minutes away from eating/drinking anything. TTFD is a form of thiamine that his Highley bioavailable and gets into the cells easier than most other forms of thiamine. Every 3 days the dose was increased by 250 mg up to the dose of 750 mg. Nah keep going bro I have 10 mercury fillings in my mouth and when I first started taking ttfd I thought I was going to die but I soon realized that I felt like that bc when you increase b1 it depletes potassium I increased potassium and felt a lot better throw in some fruits anything that contain potassium continue taking ttfd and take a toxaprevent before bed The difference has been literally life changing. It is essential for glucose metabolism, and it plays a key role in nerve, muscle, and heart function. After about 2-3 weeks, I felt almost normal. By boosting dopamine levels, thiamine TTFD can help alleviate depression symptoms and enhance mental health. Mar 23, 2017 路 Sway test guy!! It’s the cure you need to lean or sway test everything ! You stupid doctors won’t heal you they don’t know anything they let me be horribly sick to point of wanting to kill myself until I finally was able to sway test that I had a gene disorder and my white blood cells weren’t going through the nerve some facts like they should too battle the mini growths and tumors in B vitamins, namely B1 (Thiamine) usually facilitates the process to which your liver can break down alcohol, and eliminate it efficiently. So does black tea. They also recommend magnesium because it works with the thiamine. Oct 7, 2019 路 Thiamine and metformin compete for use of the thiamine transporter, THTR-2, that moves these chemicals into the body. That's how I do it. I use thiamine as well in the form of B-complex. Thiamine or vitamin B1 is a water-soluble vitamin found in both plant-based and animal-derived foods. I started taking high dose thiamine for CFS type symptoms (and aware of the paradox reaction). Is it MANDATORY to take B1 with magnesium or just a recommendation? I am taking Mg malate now and gives me good energy. After doing some research I discovered this concept called "Magnesium Intolerance" and decided to try adding Thiamine. I tried thiamine recently and it's been helping me alot. A few months ago I saw some posts on reddit recommending thiamine as a possible aid. Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Title: Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex Abstract: A physically active lifestyle is associated with better health in body and mind, and it is urgent that supporting agents for such lifestyles be developed. My functional doctor was able to determine that my gut does not absorb vitamins properly. I read somewhere that thiamine (Vitamin B1) helps with raynaud's syndrome, chronic fatigue, depression and other conditions. For each symptom you need to take a different form of thiamine. I probably wasn’t even Thiamine deficient. Thiamine supplementation is well tolerated by most people but you should start with low doses and slowly titrate up. B vitamins such as thiamine contribute to a healthy gut , and thiamine in particular has therapeutic potential in treating this general constellation of issues , , . Get support. My guess is that the thiamine stimulates my already hyperacidic stomach, so more acid reaches my throat causing irritation. It is also known as vitamin B1. I reckon it was endothelial damage from calcium and thiamine deficiency itself on top of the endotoxin build up from constipation. Hope this is useful or interesting. I took 200mg and I was knocked out for the whole weekend, I couldn't get up from the couch, the fatigue was intense lol I'm still a little traumatized by it, but I'm not giving up, haven't tried it since then but I plan on starting at 50mg mix in it with coconut water sipping it through the day with cofactors. I started taking Thiamine TTFD 100mg a day about 6 weeks ago ( with B complex & Magnesium, Potassium, etc. High dose thiamine (HDT) therapy is currently being used to treat neurodegenerative issues like POTS, IIH, depression, CFS, fibromyalgia, elevation sickness, sleep apnea, etc. Berg talks about the importance of B1 as well for another reference. I wish I could help more :( Thiamine tablets improved my baseline, I have been taking them ever since which is 2 years now. Thiamine is intimately involved in carbohydrate metabolism. Thiamine requires magnesium, so include a magnesium supplement at 100 -200 mg. You can take some benfothiamine on top of it for it's unique benefits and get extra thiamine levels higher with it's larger dosage. It additionally normally appears in tablet shape as a supplement. That’s also a hefty dose of sulbutiamine that would noticeably affect almost anyone, regardless of any thiamine deficiency. I initially started with 100 mg thiamine and 50 mg thiamine disulfide. Thank you. Clearly there are things that help to slow it down, I wish medical community was more active in providing these solutions instead of just tossing some generic symptom-masking treatment from the 70s on the problem. THe other nutrient that has been helping me a ton is ALCAR 500 mg (acetyl L carnitine which is a form of carnitine) but I've only been taking it a few days so I am not ready to do a full report yet, gotta see long term. But the thiamine felt unbalanced like it wasn't absorbing properly. My uncle's insights led me to explore the science behind thiamine TTFD and its broader applications. I was very enthusiastic then I read that it was a "pro-DHT" vitamin. Jul 24, 2024 路 Age: Up to 20%–30% of older adults have some degree of thiamin deficiency. I get low in thiamine because I like foods that have anti-thiamine factors (Wikipedia it; tea, coffee, raw fish, then sugar and alcohol just deplete it; there’s a reason the benfotiamine for was invented in Japan!). Several people in the thiamine Facebook group do this to counteract the symptoms of hyperacidity. 5 percent report using generic oral thiamine, which is often And looking up AC + thiamine I found: "Without thiamine (thus TPP), pyruvate could not make the conversion to acetyl-CoA (with the aid of choline, also in the B family) to become acetylcholine. However, "DHT" is the hormone responsible for alopecia in men. Thiamine and Muscle Contraction It can be said that thiamine, in its active form of thiamine pyrophosphate (TPP), is directly involved with the release For Lonsdale everything is the fault of vitamin b1 deficiency and all the ills of humanity can be cured by supplementing it, all sources always return either to him or to Overton, my humble opinion is that it depletes much more than it helps, all my neuropathies came back much stronger after using it and now I'm back to using B12 injections, not to mention the side effects in my heart FWIW I take thiamine nitrate 125mg (equiv. I get reflux because I don’t produce enough stomach acid. I've been infected and had long haul 4x now and have been in pretty bad shape so it'll take awhile to completely bounce back, but overall I firmly believe thiamine deficiency or somehow covid affected thiamine transport/mitochondria is the reason we're in this mess. EONutrition and other 'youtube pseudo-science guys' are suggesting that normal Thiamine forms are sufficient for healthier people but for those with potential chronic illness may be better taking more active forms such as Thiamine TTFD. 27 votes, 59 comments. For me, it took three attempts. That's in order of bioavailability from lowest to highest. I would take it for 3 months then take a week or 2 off. Benfotiamine & TTFD will also cross the Blood Brain Barrier. As you probably know, COVID can deplete thiamine, and post COVID symptoms resemble thiamine. Jul 17, 2017 路 Recovery depends upon supporting mitochondrial recovery. White hairs started growing brown again. Rhonda Patrick here. Unlike some B vitamins, there does not appear to be any known tolerable upper limit for B1. BUT I was also experiencing unwanted side effects, such as anxiety, sleep disruption, and also the benefits of magnesium finally just mostly disappeared after a full year of supplementing. You have regular B1 (usually Thiamine HCL or mononitrate), Benfotiamine, and TTFD (Thiamine Tetrahydrofurfuryl Disulfide). Thiamine deficiency disease in its end stage is called Beriberi and apparently this means "I can't, I can't" translated. I recently had bloodwork come back with a thiamine deficiency due to Celiac Disease, I do not absorb vitamins well. ) to treat low energy, brain fog & anxiety. Sep 29, 2021 路 Thiamine may be tested from whole blood, erythrocytes, serum, plasma, and urine. 58 mg (48 percent DV*) Lentils: 1/3 cup dried, or about 1 cup cooked — 0. All of the patients were well above normal for thiamine serum levels both before and after treatment. To counteract this, you can take 1/4 to 1/2 teaspoon of baking soda once a day. . I tried my first 100 mg Thiamine HCL with my regular mag supplements in the night and I could not believe it! I had the most restful sleep I've ever had! I tried it the next day and same good sleep again! TTFD is the gold standard by far. Always take thiamine with water only. Alcohol depletes the body of thiamine. For example, scientific research reviewed in this article has indicated that roasting (140 °C for 25 min or 160/170 °C for 15 min) nuts caused thiamin loss of about 11-84%, cooking milk resulted in thiamin loss of 8-12%, and ultra-high temperature processing 40-50% loss. 2 percent report using oral benfotiamine, 10. Thiamine mononitrate is the form of thiamine (nutrition b1) most normally used to support foods. Thiamine is a carbonic anhydrase inhibitor (check pinned post on my profile). 300mg BFT is not excessive. Hi, Does anyone experienced Thiamine paradoxical reactions like: sometimes makes me tired/sleepy, tension in the head, confusion, migraine, feeling like my body is in heat but I'm shacking from cold, strange/bad taste in mouth, nauseate, tingling feeling, some flue-like symptoms, vertigo, tooth pain and many more, symptoms actually migrating Worse around times of seasonal allergies. Thiamine hydrochloride for some reason doesn't kick start the actual activity of thiamine in the system. My interview of Andrew Huberman is a tour-de-force on the brain and reward systems: dangers of spiking dopamine without effort, why you shouldn't rely on stimulants (like nicotine) when lacking motivation, his workout & supplement routines, using NSDR to boost dopamine, and more It's from the book 'Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition' by Derrick Lonsdale and chandler marrs. I've found that taking 500-1000mg Thiamine HCl substantially reduces my fatigue*, but at the expense of worsening my already cobblestoned throat. I add some to hot water before I go to bed. " There are some really long, complex videos and I think some people really overthink it. If you're talking about the coconut oil, I'm using a brand called sport research organic MCT oil. It's kind of like having stores of it in our bodies, yet the system that utilizes it has been shut off. Idk. Hi, Does anyone experienced Thiamine paradoxical reactions like: sometimes makes me tired/sleepy, tension in the head, confusion, migraine, feeling like my body is in heat but I'm shacking from cold, strange/bad taste in mouth, nauseate, tingling feeling, some flue-like symptoms, vertigo, tooth pain and many more, symptoms actually migrating A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine Hi, Can anyone shed some light on how each different form of Thiamine would need to be dosed to get the same effect? For example, if a person was achieving desired effects by doing a higher dose of Thiamine Hcl at say 500mg, how much of these other forms of thiamine, such as benfotiamine, sulbutiamine and TTFD, would it take to reach the equivalent dose? Therapeutic range for thiamine HCl is 200-1800. I personally found out about this a week ago because I was having every single symptom of “wernick-korsakoff syndrome” which apparently is a thiamine deficiency induced by alcoholism. Lucky to be alive was having what felt like minor heart attacks up until thiamine. Jun 3, 2021 路 Nearly half (49. Thiamine and SIBO. I got some immediate results and some results are still showing up now as I try new forms (currently TTFD, which is particularly effective for brain and gut, not only does it have good absorption but because it's a fat it actually gets pulled into cells _without_ requiring activiation fo the thiamine transporters, which ironically become I recently read here that the Ashwagandha + L-Theanine combination has helped many people gain significant fluency, however, my speech therapist suggested to me that Thiamine may help, even more so accompanied by Magnesium, I had not heard this before and wanted to know if any of you tried it and what your results were. I have taken B vitamin complexes before, but their levels of thiamine are much lower than a typical B1 supplement alone. Yes, thiamine (vitamin B1) together with magnesium gives me the most calm and ambient feeling. Maybe joint pains. Itchiness, like histamine effect. 1 – 4. Possibly better choices might be benfotiamine or sulbutiamine, versus thiamine, due to significantly higher absorption. I only took a tiny amount out of the 100mg capsule, so maybe it was around 5mg. And you can't store pure thiamine for long in the body because it's not soluble in fat. Coffee blocks thiamine. , there are different symptoms of deficiency. For research, treatments, and personal stories regarding Chronic Fatigue Syndrome (CFS)/Myalgic… A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine Hi there! A few months back, I posted here about how magnesium and Vitamin D have been a big help to me in terms of improved mood, libido, etc. Free thiamine, TMP and TTP are found primarily in serum, plasma, and urine. Sometimes, adjustments in dosage can lead to changes in symptoms, and it's important to proceed with caution. Without sufficient thiamine, the brain may struggle to produce enough neurotransmitters, resulting in various neurological symptoms. In other words, you can’t diagnose yourself as having a thiamine deficiency just because taking a lot of sulbutiamine made you feel better. I've mentioned benfotiamine, the fat soluble thiamine, that one's expensive. TTFD is the only form which will bypass thiamine transporters. Personally, I use a magnesium glycinate formulation. Easily distracted. There are other forms of thiamine than mononitrate. The internet told me I needed tons of Thiamine (Vitamin B1) since I drank 4-5 beers everyday. In your body, thiamine separates from the nitrate group and is used for many purposes. I must have been deficient cause I feel pretty normal after taking mega doses. He goes into details about it in his book called “thiamine deficiency and high calorie malnutrition”. Thiamine mononitrate is a waste of time, IMO. Possible causes include low dietary intake of thiamine, a combination of chronic diseases, use of multiple medications, and low absorption of thiamin as a natural result of aging. Coffee and tea also inhibit thiamine absorption. I have a feeling I've been chronically low on thiamine due to lack of thiamine in diet and previous coffee habit for a long time. Thus, with all this information taken together, sufficient thiamine may improve uptake and r/Thiamine: A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine I've been suffering with extreme fatigue and brain fog for around 15 years. The 300mg BFT dose doesn't produce 300mg of thiamine diphosphate (ThDP) which is the bioactive form of thiamine. I could be another idiot on Reddit, taking for the sake of talking. I know this treatment has been particularly useful for those with CFS/ME, POTS, autoimmune diseases, and EDS. doi: 10. I think I'm going to give thiamine HCl a go instead and consider switching back to allithiamine once I've built up a bit on HCl. But high dose thiamine is safe, especially in the short term. I started off with Thiamine Mononitrate and then got some Benfotiamine, man the Benfo is potent, it speeds up my heart a little bit and makes me really energized, almost anxious. New comments cannot be posted and votes cannot be cast. Too much so for me to be able to try pushing through. Lipothiamine is a good choice and should help you to tolerate the other B vitamins better. 53 mg (44 percent DV I've read across Reddit (namely r/MCAS) that some are hesitant to try thiamine because it's a DAO inhibitor; I haven't found this to be a problem, it's a weak DAO inhibitor if anything, YMMV. I have tried every different form of thiamine supplement and jury is still out if it causes problems for me (brain fog, fatigue, anxiety). Tell me how to take thiamine please? On an empty stomach or during a meal? Thiamine in liquid dropper form is cheap on Etsy or you can make your own if you buy thiamine HCL powder. Thiamine deficiency can progress to Wernicke’s encephalopathy or Wernicke-Korsakoff syndrome (WKS) which can be deadly and requires medical treatment. There are better days and worse days but one shouldn't worry too much after a bad day. We would like to show you a description here but the site won’t allow us. 1111/nyas. This vitamin plays a critical role in energy metabolism and, therefore, in the growth, development, and function of cells . All the B's, thiamin (B1), B12, and Biotin or take super B complex: Vitamin B complex includes B1, B2, B3, B5, B6, B7, B9, and B12. Consult with a dietitian or your doctor regarding supplementation. 66 mg (216 percent DV*) Black beans: 1/3 cup dried, or about 1 cup cooked — 0. See: Thiaminases and other Antithiamin Factors. Too much will put your other B vitamins out of whack. Patient 2 received intramuscular shots of 100 mg/ml thiamine every 4 to 7 days. One of them has 40mg of thiamine, and another has 110mg per capsule, which is a big jump. If you don’t get the usual effects from your magnesium supplements, maybe try a bit of thiamine with it. So I will dose myself with thiamine (vitamin B1) slowly and only 1000mg of thiamine HCL, which is water soluble thiamine (or the "normal" thiamine). Oh, benfo is supposed to be better because it's a fat soluble precursor and more easily passes thru the cell membrane, THEN, already in the cell, it's converted into active thiamine, Supposedly people with my condition (fibromyalgia) are supposed to have dysfunctional thiamine transporters. Jan 31, 2024 路 Thiamine, also known as thiamin and vitamin B1, is one of the 8 B-complex vitamins and is classified as a water-soluble B vitamin. I have gastro issues like slow emptying of the stomach and slow motility. Magnesium is very beneficial to take with thiamine. Don’t take my word for it tho. He’s a paediatrician and used high dose thiamine to treat children with defective mitochondria since birth and it Edit: didn't get any response but have found out the hard way: it made me feel extremely wired and anxious. I’m using a protocol from hormonesmatter. Thiamin is naturally present in some foods, added to some food products, and available as a dietary supplement. Side effects from TTFD 50 mg was same as thiamine HCl, but with added effects. A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine You need to be taking magnesium also if you have a thiamine deficiency, because thiamine needs magnesium as a co-factor. I've gained back (and more, but that's steroids I thi We would like to show you a description here but the site won’t allow us. What dose of thiamine per day helped you? (There are some metabolic conditions known to medical science, where high dose thiamine can work as a treatment. Experimenting with high doses of thiamine should be quick, safe, and way more affordable than most things on this subreddit. com- starting with thiamine mono nitrate, then going to move to thiamine hcl, then to benfotiamine, then to lipothiamine. Thiamin (or thiamine) is one of the water-soluble B vitamins. thiamine 10mg) daily. So, using thiamine in large doses at the same time as your metformin could lead to decreased uptake of your diabetes medicine. I can’t speak to thiamine directly, but just from listening to interviews with Amber O’Hearn, I got the impression that in the absence of plants, our bodies absorb vitamins and minerals so much better and different metabolic pathways are created and we use vitamins and minerals far more effectively, which is why the typical RDAs etc don’t really apply anymore. Throw a ketogenic diet in there to produce ketones that reduce inflammation, fuel and heal the brain to resolve neurological issues and use those same ketones to balance the immune system and you will likely have your life back in a few months. For instance MSUD, when one of the enzymes that uses thiamine has less than usual function, but that function can be increased with extra thiamine, for some individuals with MSUD. , magnesium) or even with generalized severe acute malnutrition Very expected from TTFD, it's a powerful form of thiamine. I feel like Thiamine is helping me with that stuff. I gave up coffee and black tea because it blocks thiamine. Thiamine is a great supplement I've been supplementing with TTFD, a really bioavailable form of vitamin b1 that's supposed to be able to cross the BBB and be used by your body even if your body has trouble absorbing other forms of thiamine. For the past 9 days I have taken 100 mg of Benfotiamine combined with 800 mg of Potassium Citrate 250 mg of Magnesium Bisglycinate Vitamin B complex (with 10 mg Thiamine HCL) Vitamin B2 10 mg (extra since I have heard B1 requires more of B2) If you search in google scholar "Thiamine Glutamate" "Thiamine GABA" "Thiamine corticosteroids" "Thiamine magnesium" All studies will open up! I know it's hard at the beggining but after years of nootropics you will have all knowledge in your head and you will know how every thing affect you. true. Patient 1 and 3 took 600 mg/day oral thiamine. A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine Tried Vitamin B1 Thiamine HCL as it was being touted online as the main vitamin deficiency that causes anxiety. Too much magnesium can give you heart problems and stuff. I have read a couple of times (mostly on reddit) that Thiamine works synergistically with magnesium and that thiamine may even help reduce some of the side effects experienced with magnesium. It is possible that because I was already supplementing with thiamine when I did get covid my symptoms were less severe. As discussed Thiamine is an essential cofactor for processes in the body. A great resource for learning more about Thiamine is EO Nutrition/Elliot Overton on Youtube. Reply reply We would like to show you a description here but the site won’t allow us. From whole blood, all three derivatives of free thiamine can be obtained. Thiamine is the only thing that seems to clear up these symptoms for me. In its end stage it's called Beriberi and you can google what this means. Thiamine in general is a good nutrient for mitochondria. Hey. As a poster below mentions, lack of thiamine causes wet-brain disease, or Wernicke-Korsakoff syndrome. Thiamine is a carbonic anhydrase inhibitor, so it does create more acidity with high enough doses. I found this guy in YouTube that talks about thiamine deficiency and SIBO- EO nutrition- and thought it was worth a shot. Thiamine is in general pretty good for the body. I've been taking 300mg+/day Thiamine HCl for over a year now. The thiamine helped immediately with POTS symptoms, including the brain fog and energy. Derrick Lonsdale used it to treat genetic mitochondrial diseases. In contrast, thiamine and other B vitamins are adequately absorbed in a healthy gut . Hi all! I have been reading intriguing studies on the use of high dose thiamine + magnesium supplements to help with fatigue and brain fog. Salicylate intolerance is the main one. However, some sites say that thiamine is good for hair health As for the 100mgs of thiamine, I assume you're taking B100 which in my experience usually contains Thiamine HCl. I also crave this powdered magnesium substance called Calm. Well it's been going great for about a month, taking 50mg in the morning and 50mg at night. When it comes to supplements/vitamins I usually try to stick to Thorne or Pure Encapsulations, even though they can cost a lot more. Curious if consuming too much B1 can deplete magnesium if you’re already low? I’m borderline deficient in mag despite taking high doses daily. Riboflavin is used up by thiamine's (and the other B vitamins') metabolic processes and its absorption is improved given sufficient B1 and B5 anyway. In my case high dose thiamine made my life worth living again within a really short time frame, but it wasn't a straight curve up. The worst thing is most websites just call it "thiamine" or "B1" instead of differentiating between the synthetic compound and the natural compound. The biggest/hardest symptom I've dealt with all this time was extreme exhaustion. So I read this book all the same, with the idea that perhaps thiamine treats a syndrome of neurological problems. I tried varying doses from 100mg up to 2000mg a day, but in the end found that 500mg taken just before going to bed was most effective. I knew about paradoxical reactions, so this led me to order thiamine tetrahydrofurfryl disulfide (TTFD). 1 percent) of respondents report using oral thiamine hydrochloride, the thiamine form used in most of the studies of high-dose thiamine to date, while 18. I have tried thiamine hcl, low dose, did not see anything. I get painful fire farts when I eat sodium mononitrate, and now I'm back on the toilet after eating thiamine mononitrate. I'm taking the brand Thiamax for TTFD. So you still have room and time for adjustment. As regards your question: thiamine deficiency can be VERY severe. 100 mg thiamine hydrochloride and 250 mg magnesium citrate. Only supplementing magnesium could lower B1 and only supplementing B1 could lower magnesium, so it's a good combination. Thiamine deficiencies are relatively uncommon in developed countries unless you have a poor diet or are an alcoholic. I thought thiamine HCl alone was gonna be enough, but I had to give it a try. For the headaches my neurologist has me on B4 and Magnesium, which has also helped. Background: I was diagnosed with Hashimoto's and had half of my thyroid removed in high school (over 20 years ago). Normal values for thiamine were 2. [1] I’m still learning about necessary co-factors that might help make the process more effective, I am building up to mega dosing but have only just begun so time will tell. I initially supplemented with this form and had some results using 500mgs a day for two weeks. Reddit iOS Reddit Android Rereddit Best Communities Communities About Reddit [Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among It's great to hear that high-dose thiamine initially worked well for you. https So I’ve been supplementing thiamine HCl 500 mg a day, and a fat soluble thiamine disulfide 200 mg. Thiamine pyrophosphate accounts for almost 90% of circulating thiamine, 80% of which, is found in erythrocytes . g. In the absence of sufficient B1, the efficiency of this process diminishes and with this, there is more circulating alcohol for longer periods of time. Thiamine occurs naturally in specific diets, is added to food products, and is available in dietary supplements. To make sure it wasn’t a fluke, I took thiamine and magnesium again last night, and had a full night’s sleep again. There’s a paradox reaction that happens every time a dosage is raised. I've been dosing B1 in various forms for about a year. We started thiamine treatment with an oral dose of 250 mg in the morning. 3 µg/L, and normal values for TPP (Thiamine Pyrophosphate) were > 49 µg/L. Dr. Vitamin B1 is a water-soluble vitamin, as are all vitamins of the B complex. Drinking milk makes me sleepy too, it's most noticeable if I drink it in the morning. Proper megadosing and a thiamine sparing diet are amazing for treatment. koiqgqsidhpooghbsyrxvbzbicvduauovdufvekpgvebgk